N3538
Sigma
Nateglinide
≥98% (HPLC), solid
| Synonym: | Fastic, N-[(trans-4-Isopropylcyclohexyl)carbonyl]-D-phenylalanine, Starlix, Starsis |
| CAS Number: | 105816-04-4 |
| Linear Formula: | C19H27NO3 |
| Molecular Weight: | 317.42 |
| MDL number: | MFCD00875706 |
Description
| Biochem/physiol Actions | Nateglinide is a Kir6.2/SUR1 channel inhibitor and antidiabetic. It is selective for the SUR1 subtype, which is found on pancreatic islet cells. Nateglinide evokes KATP channel-dependent insulin secretion (50-200 μM) in the absence and presence of insulin. |
Properties
| assay | ≥98% (HPLC) |
| form | solid |
| color | white to off-white |
| solubility | DMSO: 5 mg/mL |
| H2O: insoluble | |
| storage temp. | room temp |
Safety
| Personal Protective Equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
| WGK Germany | 3 |
| RTECS | SQ7318950 |
References
| reference | Ball, A.J., et al., Acute and long-term effects of nateglinide on insulin secretory pathways. Br. J. Pharmacol. 142, 367-373, (2004) |
| Shinkai, H., et al., N-(cyclohexylcarbonyl)-D-phenylalanines and related compounds. A new class of oral hypoglycemic agents. J. Med. Chem. 32, 1436-1441, (1989) |
